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Journal : Bioscientia Medicina : Journal of Biomedicine and Translational Research

Gendola Leaf Ethyl Acetate Fraction (Basella rubra Linn) Reduces Spermatozoa Motility and Viability in Vitro Lusia Hayati; Joko Marwoto; Septi Purnamasari; Yuni Fitriayanti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 3 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i3.213

Abstract

A B S T R A C TBackground. The use of plants as anti-fertility in men has been done to reduce sideeffects. The Gendola plant is one of the Basellaceae family plants, which is a naturalmedicinal plant in Indonesia. Gendola leaves contain phenol compounds, flavonoids,tannins, steroids and triterpenoids which can have cytotoxic activity. This studyaims to determine the in vitro anti sperm activity of the ethyl acetate fraction ofGendola leaves on male spermatozoa. Methods. This study is an experimentallaboratory in vitro study using male sperm preparations. The sample used was 20men for each group, both the group was given the gondola leaf fraction and thecontrol group. The treatment group was given ethyl acetate fraction of Gendola leaves(Basella rubra Linn.) With a concentration of 0.05% for 5, 10 and 15 minutes, theviability and motility of sperm were calculated. Data analysis was performed usingthe Mann Whitney test (p <0.05) using SPSS release for Windows software. Results.The results showed that the ethyl acetate fraction affected the motility and viabilityof spermatozoa. When compared with the control group, the motility treatment groupobtained was classified as non-progressive. In the treatment group, the viability ofspermatozoa was significantly different at minute 5, minute 10 and minuted 15 (p<0.05). Conclusion. Ethyl acetate fraction has potential as an anti sperm inreducing sperm motility and viability.
Dermatoglyphy in Breast Cancer Patients: A Systematic Review Rara Inggarsih; Akhyar Dyni Zakyah; Lusia Hayati; Joko Marwoto; Septi Purnamasari; Arwan Bin Laeto; Masayu Farah Diba
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 11 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i11.368

Abstract

Background. Breast cancer is one of the four types of cancer among women and is the most frequently diagnosed in most countries. Breast cancer occurs due to DNA damage and genetic mutations affected by exposure to estrogen, inheritance of damaged DNA, or pro-cancer genes such as BRCA1 and BRCA2. Therefore, a family history of ovarian cancer or breast cancer increases the risk of developing breast cancer. The embryo of the breast develops around the age of 6 weeks of pregnancy. Similar to breast development, fingerprint patterns also develop during the 6-13 weeks of pregnancy. Thus, the genetic message contained in the genome occurred during that period and was reflected in the dermatoglyphic pattern.Methods. The literature search was systematically used using PubMed, Cochran, Google scholar, and other Gray literature between 2010-2020. Of the 69 publications identified, 21 met the criteria and were included in the review. The review is carried out following the provisions of PRISMA (Preferred Reporting Items for Systematic Review).Results. This systematic review showed fairly consistent findings in breast cancer patients who tended to have more whorl fingerprint patterns and larger ATD angles. For radial loops, ulnar loops and arches were minor compared to the control group potential as an initial screening tool in at-risk groups.Conclusion. Long-term and follow-up studies with larger sample sizes in various ethnicities are needed to validate dermatoglyphics in anthropometric measurements as a promising marker of breast cancer.
Risk Factors of Vesicovaginalis Fistule in Obstetric and Gynecologic Division of Dr. Mohammad Hoesin General Hospital in 2018-2020 Nabila Istighfarin; Hadrians Kesuma Putra; Eka Handayani Oktharina; Ratih Krisna; Septi Purnamasari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 3 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i3.476

Abstract

Background. A vesicovaginal fistula (FVV) is a direct pathological connection between the bladder and vagina resulting in uncontrolled leakage of urine into the vagina from the bladder. Based on the cause, fistulas are divided into two, namely obstetric fistula and gynecological fistula. The risk factors that influence the occurrence of FFV consist of obstetric risk factors (age, parity, delivery method, duration of delivery, birth weight) and gynecological risk factors (history of gynecological surgery, history of pelvic radiotherapy, history of gynecologic malignancy). The purpose of this study was to determine the relationship between risk factors and the incidence of vesicovaginal fistula. Methods. This research is an observational-analytic study with a cross-sectional method. The number of samples obtained was 74 patients who met the inclusion criteria using secondary data from medical records. Analysis of the data used is the chi-square test. Results. There were 37 people who experienced vesicovaginal fistula. Where there were 9 patients with obstetric vesicovaginal fistula (24.3%) and 28 people (75.7%). From the Chi-Square test analysis, there was a significant relationship between delivery method (p=0.029), birth weight (p=0.029), history of gynecological surgery (p=0.038), history of pelvic radiotherapy (p=0.016), history of gynecological malignancy (p=0.016). =0.010). Meanwhile, there was no significant relationship between age (p=0,347), parity (p=1,000), and duration of labor (p=0,082). Conclusion. There was a significant relationship between the delivery method, birth weight, history of gynecological surgery, history of pelvic radiotherapy, history of gynecological malignancy. There was no significant relationship between age, parity, and duration of vaginal delivery.